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Details of the study characteristics can be found in Supplementary Table S5, E. An overview of the risk of bias for RCTs is shown in Figure 2. Other studies (8, 31%) examined individuals with metabolic syndrome (including obesity) and/or cardiovascular disease. Some studies (9, 35%) included individuals who either had a histological diagnosis of prostate cancer or colon cancer, evidence of increasing prostate specific antigen (PSA), or a family history of cancer. The remaining 400 studies were assessed in full text, leaving a total of 26 eligible studies. Sensitivity analysis, using fixed-effects meta-analysis, was carried out where at least two trials were combined. Where meta-analysis was not possible or data could not be converted or utilised, results were narratively reported.
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